Dengue Fever? Bring those genetically modified mosquitoes in!

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GM-mosquito-lifecycle

A unique form of pest control was tried in Juazeiro, a city in north east Brazil, to combat dengue fever. Popularly known as the “bone breaker” it causes vomiting, severe pain in the joints and abdomen and circulatory system failure. The problem is, this fever which is primarily spread through the mosquito species Aedes aegypti, is nearly impossible to treat. So the only way to fight it; is precaution, i.e. reducing the number of mosquitoes that carry it.

2006 Prof. Frank Hadley Collins, Dir., Cntr. for Global Health and Infectious Diseases, Univ. of Notre Dame This 2006 image depicted a female Aedes aegypti mosquito as she was obtaining a blood-meal from a human host through her fascicle, which had penetrated the host skin, was reddening in color, reflecting the blood?s coloration through this tubular structure. In this case, what would normally be an unsuspecting host was actually the CDC?s biomedical photographer?s own hand, which he?d offered to the hungry mosquito so that she?d alight, and be photographed while feeding. As it would fill with blood, the abdomen would become distended, thereby, stretching the exterior exoskeletal surface, causing it to become transparent, and allowed the collecting blood to become visible as an enlarging intra-abdominal red mass, as is the case in PHIL# 9175, and 9176. As the primary vector responsible for the transmission of the Flavivirus Dengue (DF), and Dengue hemorrhagic fever (DHF), the day-biting Aedes aegypti mosquito prefers to feed on its human hosts. Ae. aegypti also plays a major role as a vector for another Flavivirus,

Keeping this fact in mind a British biotech company Oxitec has engineered a male mosquito that looks just like the usual male mosquito to the female ones in the wild. But when these mosquitoes mate, they pass onto their offspring a mutation that kills them before they are even ready to reproduce or spread the disease. Since last few years, dengue has been on the rise in Brazil with a horrific figure of 16 million new cases every year. The problem doesn’t end here. Many of the disease carrying mosquitoes have become resistant to pesticides leaving a slim window to combat the disease. So over a one year period, researchers from Oxitec released the genetically modified males in the north east area of Brazil and monitored the resulting eggs. The study found a terrific drop of 95 percent in the number of disease- carrying mosquitoes as compared to a control group in a neighbourhood.

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The success of this experiment has encouraged the researchers to scale up their efforts to completely eradicate dengue and the insects carrying it.

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Author:Technology Blog

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